On November 18, 2025, HLN released a new version of the open-source Immunization Calculation Engine (ICE) software, with support for professional medical society-aligned COVID-19 recommendations for the 2025-2026 respiratory season, mpox updates, and a technical upgrade. ICE is a state-of-the-art open source software system that provides clinical decision support for immunizations for use in Immunization Information Systems (IIS), Electronic Health Record (EHR), and Personal Health Record (PHR) Systems.
The latest release supports evidence-based COVID-19 guidelines from the American Academy of Pediatrics (AAP) for patients through age 18 years and the American Academy of Family Physicians (AAFP) for children, adolescents, and adults. The release follows input from the ICE Advisory Group and HLN’s re-affirmed commitment to sourcing ICE updates from evidence-based guidelines. In addition to the COVID-19 updates, the release includes important updates for the Mpox vaccine group and an update to Java 21.
What’s New in ICE
- COVID-19 Seasonal: Added support for the 2025-2026 season, with a season start date of 8/27/2025. Added support for CVX 334, COVID-19, mRNA, LNP-S, PF, 10 mcg/0.2 mL, Moderna (mNEXSPIKE, 12+ yrs).
- COVID-19 Pandemic: Added a vaccine start date of 12/11/2020 for CVX 211 and CVX 213.
- Mpox: Updated references from “orthopoxvirus” to “mpox”. Added support for CVX 325, vaccinia (smallpox, mpox), unspecified (NOS). Updated live vaccine interval handling for mpox vaccines.
- General Rules: Added two new general rules: Evaluation of Shots Prior to the CVX Start Date and Evaluation of Shots After the CVX End Date.
- Core Service: Updated the ICE service from Java 17 to Java 21. The Java update requires users who download the zipfile distribution to upgrade to Java 21. Also, the service can now be used with either Tomcat 10 or Tomcat 11; previously, Tomcat 11 was not supported.
Please see the Release Notes for additional details. Try ICE with the ICE Client Application and download ICE v2.51.1 today. Questions? See our wiki or reach out to the ICE team at ice@hln.com.