On November 12, 2026, HLN released a new version of the open-source Immunization Calculation Engine (ICE) software with clinical logic and technical updates.
What’s New in ICE
Clinical logic updates
- Hepatitis B:
- Added support for CVX 193 (Hep A-Hep B, adolescent/pediatric (non-US)).
- Updated forecasting for adults aged 19–59 years with no Hepatitis B doses on record to better reflect the continuation of childhood vaccination recommendations into adulthood.
- MMR: Updated dose evaluation rules to support validation of a second MMR dose administered at age 19 years or older.
- Meningococcal ACWY:
- Updated evaluation of the discontinued MPSV4 vaccine (CVX 32); these doses no longer count toward series completion.
- Lowered the absolute minimum age for MenQuadfi (CVX 203) based on AAP guidance.
- Added a four-day grace period to the age-16 threshold for completing the 2-dose MCV4 series with a single dose.
- Pneumococcal: Updated the supplemental recommendation text for adults aged 19–49 years to indicate that routine adult pneumococcal vaccination begins at age 50 years.
Technical updates
- Configuration: Added separate configuration settings to control the return of series and season information for evaluations and recommendations. Note: Implementers using the previous setting must update their configuration before upgrading.
- FHIR API: Updated the experimental FHIR API response format. Organizations using this interface should review and test their integrations before upgrading. Interested in providing API feedback? Reach out to us at ice@hln.com.
- Technical Documentation: Migrated the ICE Implementation Guide and ICE code values documentation to the ICE GitHub repository.
See the latest logic updates in action using CDS Insight, a free tool that allows users to interact with HLN Consulting’s locally-hosted instance of the latest version of ICE. Simulate patient scenarios and receive immunization evaluations and recommendations based on the latest ICE rules.
Please see the Release Notes for additional details and download ICE v2.61.1 today.
Questions? Please reach out to the ICE team at ice@hln.com.